Endocrine Abstracts

Introduction: The presence and type of atherosclerotic plaque is associated with future cardiovascular events (CVE). We previously described that increased frequency of plaques is associated with specific features in type 1 diabetes. The aim of the present study was to investigate the characteristics of atherosclerotic plaques in patients with type 1 diabetes mellitus (T1D).Methods: A cross-sectional study of 174 subjects with carotid atherosclerotic pla...

Background: Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetic complications. Our aim was to assess differences in food and nutrient intake of type 1 diabetic patients with and without diabetic retinopathy (DR).Subjects and methods: This was a two-center, cross-sectional study in patients diagnosed with T1DM with and without DR. Su...

Background: An association of pregnancy outcomes with subclinical hypothyroidism have been reported, however, there still exists a strong controversy regarding whether subclinical hypothyroidism ought to be dealt with or not. The latest American Thyroid Association’s guideline gives support to a higher TSH upper reference range of 4 mIU/l than the one proposed a few years ago of 2.5 mIU/l for the first trimester of pregnancy, in the absence of local normal ranges of TSH. ...

Introduction: Morbid obesity (MO) is a major global public health problem, associated with a significant economic burden, both due to its high prevalence and the number and severity of its comorbidities. MO is associated with a high degree of difficulty to lead a normal social and working life. Weight loss is effective in decreasing these risks and to reduce disease severity. Bariatric surgery (BS) is an effective therapy for sustained weight loss and for the improvement of th...

Objective: Pituitary apoplexy (PA) is a rare, sometimes life-threatening clinical syndrome. However, some cases are subclinical (SPA), just revealed by MR performed during the follow-up of known pituitary adenomas or due to other conditions. Our aims were to describe the clinical characteristics and evolution of the patients with SPA compared with patients with acute PA (APA). We also compare the results of surgery vs conservative management in the APA group.<p class="abst...

Introduction: Up to 30% of the thyroid nodules studied with fine needle aspiration biopsy (FNAB) are reported as Bethesda III, a category that does not rule out malignancy. One technique that could help to decide if there is a surgical indication is (99 m) Tc-sestaMIBI scintigraphy (MIBI).Material and methods: All patients with a Bethesda III result were prospectively included, and 99 Tc-MIBI scintigraphy was performed prior to surgery. All exams, includ...

Results: Main clinical, analytical and polygraphic data: 58.1±6.4 years, body mass index 32.4±5.4 kg/m2, 70.4% female, HbA1c 8.0±1.9%, AIH 27.4 events/hour (in the range of severe sleep apnea and hypoapnea index), and CT90% 32.9%. Nocturnal concentration of urine total metanephrines were higher than diurnal levels (226±12 vs 98±13 μg/l; P=0.085). In addition, its nocturnal concentration was significantly associated, in a positi...

IntroductionAnorexia nervosa is a severe and potentially lethal eating disorder. We report hereby the cases of two female-to-male transsexual patients whose anorexia nervosa was promptly resolved when they started gender-affirming hormone therapy.MethodsReview of the patients’ clinical records and of the relevant literature.Case reportsA 15 year-old male tran...

Medical treatment of acromegaly is currently performed through a trial-error manner using somatostatin receptor ligands (SRLs) as first-line drugs. Average SRLs response is seen in 50% of cases; subsequent drugs are indicated following clinical judgement. Some biomarkers either before or after surgical failure have been reported to predict SRLs response, including intensity in T2 weighted MRI, short acute octreotide test (sAOT), and different molecules such as SST2 and E-cadhe...

We previously described a short version of the acute octreotide test (sAOT) for predicting somatostatin receptor ligands (SRLs) response in patients with acromegaly1. In the present work, we prospectively reassess the sAOT ability to identify SRLs response in patients from the ACROFAST study using the current GH standards and control criteria and we also correlate sAOT values with E-cadherin tumor expression. Methods: Patients from the ACROFAS...